"As a pediatric scientist and the mother of two children, I am passionate about giving children the best possible start to a full and healthy life."

Sallie Permar, MD, PhD

Recent Publications

David R. Martinez, Youyi Fong, Shuk Hang Li, Fang Yang, Madeleine F. Jennewein, Joshua A. Weiner, Erin A. Harrell, Jesse F. Mangold, Ria Goswami, George Seage, Galit Alter, Margaret E. Ackerman, Xinxia Peng, Genevieve G. Fouda, and Sallie R. Premar. In Press. “Fc characteristics mediate selective placental transfer of IgG in HIV-infected women.” Cell Press. April 2019

Mangan RJ, Stamper L, Ohashi T, Eudailey JA, Go EP, Jaeger FH, Itell HL, Watts BE, Fouda GG, Erickson HP, Alam SM, Desaire H, Permar SR. Determinants of Tenascin-C and HIV-1 envelope binding and neutralization. Mucosal Immunol. 2019 Apr 11;. doi: 10.1038/s41385-019-0164-2. [Epub ahead of print] PubMed PMID: 30976088; NIHMSID:NIHMS1525701.

 

Dennis M, Eudailey J, Pollara J, McMillan AS, Cronin KD, Saha PT, Curtis AD, Hudgens MG, Fouda GG, Ferrari G, Alam M, Van Rompay KK, De Paris K, Permar S, Shen X. Co-administration of CH31 broadly neutralizing antibody does not affect development of vaccine-induced anti-HIV-1 envelope antibody responses in infant Rhesus macaques. J Virol. 2018 Dec 12. pii: JVI.01783-18. doi: 10.1128/JVI.01783-18.

Nelson C, Vera Cruz D, Su M, Xie G, Vandergrift N, Pass R, Forman M, Diener-West M, Koelle K, Arav-Boger K, and Permar, SR. Intrahost dynamics of human cytomegalovirus variants acquired by seronegative glycoprotein B vaccinees. Journal of Virology. Nov 2018 In Press.

Himes JE, Goswami R, Mangan RJ, Kumar A, Jeffries TL Jr, Eudailey JA, Heimsath H, Nguyen QN, Pollara J, LaBranche C, Chen M, Vandergrift NA, Peacock JW, Schiro F, Midkiff C, Ferrari G, Montefiori DC, Hernandez XA, Aye PP, Permar SR. Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys. Mucosal Immunol. 2018 Nov;11(6):1716-1726. doi: 10.1038/s41385-018-0067-7. Epub 2018 Aug 16. PubMed PMID: 30115994.

Martinez DR, Fouda GG, Peng X, Ackerman ME, Permar SR. Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG? PLoS Pathog. 2018 Aug 30;14(8):e1007161. doi: 10.1371/journal.ppat.1007161. eCollection 2018 Aug. PubMed PMID: 30161231; PubMed Central PMCID: PMC6117057.

Nelson CS, Huffman T, Jenks JA, Cisneros de la Rosa E, Xie G, Vandergrift N, Pass RF, Pollara J, Permar SR. HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions. Proc Natl Acad Sci U S A. 2018 Apr 30. pii: 201800177. doi: 10.1073/pnas.1800177115. [Epub ahead of print] PubMed PMID: 29712861.

 

Kumar A, Smith CEP, Giorgi EE, Eudailey J, Martinez DR, Yusim K, et al. (2018) Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma. PLoS Pathog 14(4): e1006944. https://doi.org/10.1371/journal.ppat.1006944

 

Eudailey JA, Dennis ML, Parker ME, Phillips BL, Huffman TN, Bay CP, Hudgens MG, Wiseman RW, Pollara JJ, Fouda GG, Ferrari G, Pickup DJ, Kozlowski PA, Van Rompay KKA, De Paris K, Permar SR. Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques. mSphere. 2018 Jan 10;3(1). pii: e00505-17. doi: 10.1128/mSphere.00505-17. eCollection 2018 Jan-Feb. PubMed PMID: 29359183; PubMed Central PMCID: PMC5760748

Fouda, GG, Martinez, DR, Swamy, GK, Permar, SR. 2018.The Impact of IgG Transplacental Transfer on Early Life Immunity. ImmunoHorizons January 1, 2018, 2 (1) 14-25; DOI: https://doi.org/10.4049/immunohorizons.1700057

 

Permar SR, Schleiss MR, Plotkin SA. 2018. Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections. J Virol 92:e00030-18. https://doi.org/10.1128/JVI.00030-18.

Itell HL, Nelson CS, Martinez DR, Permar SR.Maternal immune correlates of protection against placental transmission of cytomegalovirus.Placenta. 2017 Apr 20. pii: S0143-4004(17)30233-3. doi: 10.1016/j.placenta.2017.04.011. [Epub ahead of print] PMID:28456432

Martinez DR, Vandergrift N, Douglas AO, McGuire E, Bainbridge J, Nicely NI, Montefiori DC, Tomaras GD, Fouda GG, Permar SR. Maternal Binding and Neutralizing IgG Responses Targeting the C-Terminal Region of the V3 Loop Are Predictive of Reduced Peripartum HIV-1 Transmission Risk. Journal of virology. 2017; 91(9).PMID: 28202762

PMCID:PMC5391478

Duke University School of Medicine

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